COMPARATIVE EVALUATION OF HEMODYNAMIC STABILITY AND RECOVERY DURING CONSCIOUS SEDATION BY DEXMEDETOMIDINE WITH FENTANYL V/S KETAMINE WITH FENTANYL IN DILATATION AND CURETTAGE

*Dr. Virendra Sharma MBBS., M.D, Dr. Smita Barya M.B.B.S, M.S, Dr. Prakash Chandra Audichya M.B.B.S, M.D, Dr. Sameer Goyal MBBS., M.D, Dr. Vijay Kumar MBBS., M.D. and Dr. Jyoti Petkar MBBS., MD

ABSTRACT

Background: The aims of present study are to compare the adequacy of sedation, hemodynamic and respiratory stability, time to achieve "street fitness" status by Dexmedetomidine with Fentanyl v/s Ketamine with Fentanyl in Dilatation and Curettage. Material And Method: This prospective randomized controlled study was conducted in department of anaesthesiology, Pacific Medical College and hospital. In this study 60 healthy patients of age between 18-65 years and ASA Grade I & II scheduled for Dilatation and Curettage were taken. After taking valid consent they were divided into two groups, each group comprising of 30 patients Group D+F- In this group randomly selected 30 patients were given injection Dexmedetomidine along with inj. Fentany. Group K+F- In this group randomly selected 30 patients were given injection ketamine, along with inj. Fentanyl. The scales used during the study were Aldrete’s score for post-operative recovery and Ramsay’s score for sedation. Results and Conclusion: Our study concluded that Dexmedetomidine in 1 mcg/kg with Fentanyl 1 mcg/kg has a superior hemodynamic stability in comparison to ketamine0.5mg/kg with Fentanyl 1 mcg/kg. Dexmedetomidine and Fentanyl combination is an effective modality to provide analgesia and anaesthesia for D & C procedure without significant side effects apart from bradycardia which was transient in duration and no patient required any pharmacological intervention. Dexmedetomidine is a new invention in daycare surgery with advantage of early discharge and reasonable cost.

Keywords: Conscious sedation, Dexmedetomidine, Fentanyl, Ketamine, Dilatation and Curettage.