EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

COMPARATIVE EVALUATION OF HEMODYNAMIC STABILITY AND RECOVERY DURING CONSCIOUS SEDATION BY DEXMEDETOMIDINE WITH FENTANYL V/S KETAMINE WITH FENTANYL IN DILATATION AND CURETTAGE

*Dr. Virendra Sharma MBBS., M.D, Dr. Smita Barya M.B.B.S, M.S, Dr. Prakash Chandra Audichya M.B.B.S, M.D, Dr. Sameer Goyal MBBS., M.D, Dr. Vijay Kumar MBBS., M.D. and Dr. Jyoti Petkar MBBS., MD

ABSTRACT

Background: The aims of present study are to compare the adequacy of sedation, hemodynamic and respiratory stability, time to achieve "street fitness" status by Dexmedetomidine with Fentanyl v/s Ketamine with Fentanyl in Dilatation and Curettage. Material And Method: This prospective randomized controlled study was conducted in department of anaesthesiology, Pacific Medical College and hospital. In this study 60 healthy patients of age between 18-65 years and ASA Grade I & II scheduled for Dilatation and Curettage were taken. After taking valid consent they were divided into two groups, each group comprising of 30 patients Group D+F- In this group randomly selected 30 patients were given injection Dexmedetomidine along with inj. Fentany. Group K+F- In this group randomly selected 30 patients were given injection ketamine, along with inj. Fentanyl. The scales used during the study were Aldrete’s score for post-operative recovery and Ramsay’s score for sedation. Results and Conclusion: Our study concluded that Dexmedetomidine in 1 mcg/kg with Fentanyl 1 mcg/kg has a superior hemodynamic stability in comparison to ketamine0.5mg/kg with Fentanyl 1 mcg/kg. Dexmedetomidine and Fentanyl combination is an effective modality to provide analgesia and anaesthesia for D & C procedure without significant side effects apart from bradycardia which was transient in duration and no patient required any pharmacological intervention. Dexmedetomidine is a new invention in daycare surgery with advantage of early discharge and reasonable cost.

Keywords: Conscious sedation, Dexmedetomidine, Fentanyl, Ketamine, Dilatation and Curettage.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )