A CASE CONTROL STUDY TO ASCERTAIN THE RELATIONSHIP OF METABOLIC, BIOCHEMICAL AND HORMONAL CHANGES IN WOMAN SUFFERING FROM POLYCYSTIC OVARY SYNDROME

Jehan Nizam Ansari*, Iqbal Banyameen, Sanjyot Rajendra Nikam, Ayesha Khanam Siddique

ABSTRACT

Aims: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting 9 -18% of women worldwide and a major cause of anovulatory infertility. PCOS is found to be a predisposing factor for the development of impaired glucose tolerance and cardiovascular diseases. This study was designed to investigate and compare the metabolic and biochemical characteristics of PCOS patients with control group. Methods: Young women, aged 16 to 40 years, diagnosed with PCOS (N =100) and control group (N=100) attending a tertiary care hospital was included in the study. Biochemical parameters were measured using standard procedures. Laboratory normal reference ranges were used for comparison. Results: 82.2% of the PCOS patients were in 16-20 years of age group. BMI range of the women with PCOS was 24.82. Fasting Blood Sugar, Random Blood Sugar and Hba1C all were deranged in cases. Reversal of LH/FSH ratio was also present with mean value of 2.48 in the cases. Lipid profile was highly deranged in cases with mean values of 210.08mg/dl (Total Cholesterol), 125.94mg/dl (Triglycerides), 125.11mg/dl (LDL), and 39.67 mg/dl (HDL). Serum Prolactin, FSH, LH, Thyroid Stimulating Hormone (TSH) DHEA (dihydroepiandesterone), SHBG (sex hormone binding globulin) testosterone, Prog-21 (progesterone on 21st day of menstrual cycle) level were also deranged among the PCOS patients in comparison to controls. Conclusions: BMI was high in the patients of the PCOS. Blood sugar, lipid profile and hormonal profile were deranged in PCOS patients as compared to controls.

Keywords: BMI, hormonal profile, lipid profile, PCOS.