CO-RELATION OF PLATELET VOLUME INDICES WITH LIPID PROFILE IN DIABETIC AND NON-DIABETIC PATIENTS: A CASE CONTROL STUDY

Jehan Nizam Ansari*, Archana Chirag Buch, Supreet Kaur, Sanjyot Rajendra Nikam, Rahul Nair, Mohit Rajpal

ABSTRACT

Introduction: Diabetes mellitus is a metabolic disorder on increasing trend due to modern industrial lifestyle in India. The objective of the study was to compare platelet volume indices and lipid profile of diabetic cases and non-diabetic controls and to study correlation of platelet volume indices with lipid profile in diabetic patients. Methods: A hospital based case control study was conducted among 100 diabetic cases and 100 non-diabetic controls. Various investigations including platelet volume indices and lipid profile were done in both the groups. Biochemical parameters were measured using standard procedures. Laboratory normal reference ranges were used for comparison. Results: In diabetic patients, Mean Platelet Volume (MPV), Platelet distribution width (PDW) and Platelet Large Cell Ratio (PLCR) were found to be 14.47 ± 4.536, 15.09 ± 3.544 and 30.48 ± 8.139 respectively. In non-diabetics these indices were 8.78 ± 1.117, 9.38 ± .936 and 20.99 ± 6.813 respectively. There were statistically significant differences in Total Cholesterol (TC), Low Density Lipoprotein (LDL) and Triglyceride (TG) among diabetics and non-diabetics. These differences were found in both the genders. MPV and PLCR were positively correlated with TC, TG, HDL and LDL, which were found statistically significant. Conclusion: There were significant differences in platelet volume indices and lipid profile of diabetic patients and non-diabetic controls. Positive correlation between platelet volume indices and lipid profile in diabetic patients was found which was statically significant.

Keywords: Diabetes mellitus, HbA1c, Lipid profile, Non-diabetics, Platelet volume indices.