EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

COMPARATIVE EFFICACY OF DIFFERENT ORAL IRON CHELATORS IN MULTIPLY TRANSFUSED THALASSAEMIA PATIENTS

Arakhita Swain*, Kedarnath Das, J. Bikrant Kumar Prusty and Saiprasanna Behera

ABSTRACT

Background: Thalassaemia is not that uncommon disease and it has lots of morbidities and mortalities. Repeated Blood Transfusions at regular intervals, still remains as the treatment of choice due to very many reasons, leading eventually, to iron over loading and its complications. The management of iron overload in these patients requires the administration of iron chelators continuously and evaluation of serum ferritin levels at regular intervals. This study was undertaken in the Department of Pediatrics, S.C.B. Medical College & SVP PGIP, Cuttack, in collaboration with the Department of Clinical Hematology, S.C.B. Medical College, Cuttack, Odisha during the period from January, 2012 to June, 2013 with an aim and objective to compare the efficacy of different oral iron chelators for clinical use. Materials And Methods: The study included 60 patients of Thalassaemia, out of which 50 were β-thalassaemia major and 10 β-Thalassaemia intermedia. Study population (after fulfilling inclusion and exclusion criteria) was divided into two Treatment Groups a) Deferiprone and b) Deferasirox, each consisting of 30 patients chosen randomly, for giving the drug. After detailed history and physical examination, all were investigated, given chilators and re-investigated after 6 months of chelation therapy. During statistical analysis one group acted as the control for the other group. Results: The study included 60 patients of Thalassaemia, out of which 50 were β-thalassaemia major and the rest 10 were β-Thalassaemia intermedia. Treatment Groups a) Deferiprone and b) Deferasirox, each consisted of 30 patients. Out of 60 patients, 42(70%) had significant (≥ 15%) decrease in serum ferritin level, but the decrease was more marked in Deferasirox group (41.7%) than Deferiprone group (28.3%). Conclusion: Even though both Deferiprone and Deferasirox are effective at decreasing iron burden, from the point views of several characteristics, Deferasirox is favoured over Deferiprone.

Keywords: Thalassaemia, Iron Chelators, Multiply Transfused, Ferritin, BT.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 November 2021 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR: NOVEMBER ISSUE PUBLISHED

    NOVEMBER Issue has been successfully launched on 1 November 2021.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )