EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

BETULINIC ACID-MEDIATED INDUCTION IN APOPTOSIS AND INHIBITION IN LACTATE DEHYDROGENASE ACTIVITY IN MURINE ASCITES DALTON’S LYMPHOMA

Anamika Bhaumik*, Arun Bahadur Gurung, Atanu Bhattacharjee and Surya Bali Prasad

ABSTRACT

Betulinic acid is a pentacyclic triterpenoid originally isolated from the bark of the white birch Betula pubescens, from which it got its name. Antitumor potential of betulinic acid against murine ascites Dalton’s lymphoma (DL) has been established. The light, fluorescence and transmission electron microscopy based study showed that DL cells treated with betulinic acid depicted typical apoptotic features which could be imperative in its antitumor activity. Betulinic acid treatment also caused a significant decrease in lactate dehydrogenase (LDH) activity in DL cells. Further, molecular docking study revealed the strong binding affinity of betulinic acid with LDH which could be noteworthy in resulting decreased LDH activity. Based on these findings, it may be suggested that along with the induction in apoptosis, lactate dehydrogenase could be a possible target for betulinic acid-mediated antitumor activity in DL-bearing mice, since its inhibition by betulinic acid may decrease energetic and anabolic supply to cancer cells, which could be one of the important factors to reduce the metastatic and invasive potential of DL cells.

Keywords: Betulinic acid, Apoptosis, Dalton’s lymphoma, Lactate dehydrogenase, Molecular docking.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )