SEROLOGICAL CONVERSION AFTER HEPATITIS B VACCINATION IN EXPANDED IMMUNIZATION PROGRAMME
Ajmariya M., Ghanghoriya P., Agarwal G., Kumaran K. and Mittal P.*
ABSTRACT
Objective: To observe the seroconversion rate after routine Hepatitis B immunization in pediatric infants. Methods: A prospective observational study was conducted in Department of Pediatrics, NSCB Medical College Jabalpur. 50 consecutive healthy infants were enrolled after taking informed consent from parents as per the inclusion criteria. The blood samples were collected from 40 full term infants after full hepatitis B immunization with 6, 10, 14 week schedule. The antibody (antiHBs) titer of ≥10 IU/L was considered to be protective against hepatitis B. The data was recorded, compiled and analyzed by using SPSS 20 and MS excel and appropriate statistical analysis was done. The critical level of significance was considered at P<<0.05. Result: Of the 40 babies analyzed in the study, 62.5% were males and 37.5% were females. 77.5 %( n=31) children were found to be protected against Hepatitis B. It was found that, 40% of the females were unprotected as compare to 12% males. Conclusion: The efficacy of Hepatitis B vaccination in national immunization program was found less than the desired response.
Keywords: Hepatitis B, Vaccination, Seroconversion.
[Full Text Article]
[Download Certificate]