A REVIEW ON BIOPOLYMERS AS A NOVEL BIO-EXCIPIENTS IN DRUG DELIVERY SYSTEM
Sushant Kumar*, N.V. Satheesh Madhav, Anurag Verma and Swarnima Pandey
In present time biopolymer has attracted and concentrated on its use for novel drug delivery and utilization of drug. A number of biopolymers have been isolated by Satheesh Madhav for drug delivery system and most of them are used frequently in various drug delivery systems. In current practices the vast number of plant-based excipients is used in the Pharmaceutical field. Because biopolymer have number of advantages over the synthetic polymer like biocompatible, biodegradable in nature, nontoxic, less side effect and low cost etc. Bio polymers have been successfully investigated and employed in the different types of formulation like solid, liquid, and semisolid dosage forms and are specifically useful in the design of novel drug delivery systems. At present era a number of plant based pharmaceutical excipients are available. Many researchers have explored the usefulness of plant-based materials and meet the requirements of drug delivery systems, thus compete with the synthetic excipients available in the market. A number of biopolymers like Biopolymer from extract of Ocimum basilicum, Sesamum indicum seeds, Psidium gaujava Sodium salt of Musa paradisiaca biopolymer, Cocos nucifera, Bombax malabaricum, kernels of Helianthus annus, fruit pulp of Cordia dichotoma, Mangifera indica, Lotus corniculatus, Cajanus indicus, Logelaria siceraria, Arahcis hypogea seeds ,Lallimantia royalena seeds, Annona squamosa fruit pulp, Gravia oppositifolia, Cucurbita maxima fruit pulp, Psidium guajava, Artocarpus heterophyllus are under identification and isolation. The use of these biopolymers has proved a promising and tremendous use in drug delivery due to its novelistic characteristics and minimised side effectes. These may be used in ear to brain drug targeting for treatment of different brain diseases. Madhav et.al., (2013) reported the novelistic method for formulating resealed erythrocytes loaded with Repaglinide bionanoparticles. The biopolymer was separated from Citrus sinensis and it was characterized for its physicochemical properties. This invention was also discloses a method for preparing nanoparticles along with resealing of it into goat blood. The formulation showed promising prolongability for 56 hrs apart from this it also showed promising emulsifying ability, retardability and film forming ability which was confirmed by suitable formulations. Conclusion was drawn that this is a novelistic approach significantly delivering the drug for prolonged period and the biopolymer was served as a promising excipient for delivering dosage forms. Madhav & Priyanka et.al.,(2013) reported the novelistic method for isolating the bio-polymer from vigna unguiculata by simplified economical process using anti solvent addition method and it is subjected for various physico chemical properties , spectral analysis like NMR, IR ,MASS and morphological studies like SEM and XRD in order to determined its polymeric nature and chemical nature. The novel bio polymer also possesses in built properties like emulsifiability, filmability and retardability which was confirmed by suitably formulating different dosage forms using nimuslide, Zidovudine as a model drug. The conclusion was drawn that this novelistic approach can be adapted for formulating various drug loaded SNEDDS and where as the bio polymer can be used as bio excipient for formulating various drug delivery system.
[Full Text Article]