BIOMARKERS OF INFLAMMATION AND GLYCEMIA BALANCE IN TYPE 2 DIABETIC MELLITUS OUTPATIENTS IN ABIDJAN (CÔTE D’IVOIRE)

M. CISSE-CAMARA*, F.Mansour. ADEOTI, Innocent K. KOLIA, Yves E. THE, Joseph A. DJAMAN

ABSTRACT

Background: The crucial role of inflammation in the pathogenesis of type 2 diabetes mellitus remains controversial. However, most studies suggest that the production of pro-inflammatory proteins in diabetes mellitus promotes insulin resistance and the development of type 2 diabetes. The aim of the study is to assess the evolution of markers of inflammation and glycaemia in diabetic type 2 during treatment of outpatients living in Abidjan. Methods: For this purpose, 90 subjects with type 2 diabetes untreated previously (35 to 69 years, both sexes) were recruited. According to their situation, they were equally classified into insulin dependent and non-insulin dependent and treated respectively with insulin and oral antidiabetic adrugs. Glycemia, HbA1c and CRP were determined in early and 3 months after the treatment using enzymatic methods. Results: Before treatment, there was a significant mean hyperglycemia (p < 0.001) in both treatment groups, with a higher value in insulin subjects (3.95 ±0.05 g/L). The concentration of CRP was also very high (p < 0.001) in insulin dependents (15.50 ±0.42 mg/L). Three months after treatments, the mean glycemia (1.10 ±0.02 g/L) in patients treated with insulin was much reduced against those treated with oral antidiabetics (1.50 ±0.02 g/L). However for these latter, the CRP (6.31 ±0.40 mg/L) was much reduced compared to insulin dependents subjects (10.50 ±0.02 mg/L). Conclusion: These findings support the role of inflammation in the pathogenesis of type 2 diabetes and suggests the CRP consideration in blood glucose balance order to better guide therapy combining anti-inflammatory drugs.

Keywords: Type 2 diabetes, Glycemia, Inflammation, C-reactive protein.