EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PRODUCTION OF LOVASTATIN FROM FUNGAL SOURCES AND ITS MEDICAL APPLICATIONS

Hannana Maryam, Sana Maqsood, Zuriat Jabbar and Sikandar Ali*

ABSTRACT

Lovastatin and other natural as well as synthetic statins are considered as wonder drugs for treatment of hypercholesterolemia. Statins are produced by many fungal sources mainly from Aspergillus terreus on industrial scale. Lovastatin lowers blood cholesterol levels dramatically by inhibition of hydroxymethyl glutaryl-coenzyme A (HMG-CoA) reductase which is enzyme required for catalyzing rate limiting step for de novo cholesterol synthesis. This competitive inhibition is due to structural similarity between HMG-CoA and acid form of lovastatin. Lovastatin possess a hydroxyl hexahydro naphthalene ring which is polyketide chain to which different side chains are attached. Lovastatin synthesis starts from linkage of acetate units in head to tail fashion establishing main polyketide chain. First intermediate formed during synthesis is monacolin L which is then turned into monacolin J by hydroxylation which in turn gets converted into lovastatin. Molecular studies revealed that genetic cluster involved in biosynthetic pathway includes genes LovB, LovC,LovA,LovD,LovF and Lov H. Industrially lovastatin is produced by liquid submerged fermentation but now a day’s use of solid state fermentation is gaining importance. Lovastatin serves as drug of choice for cardiovascular diseases like peripheral vascular disease, atherosclerotic plaque, peripheral arterial disease, cerebro vascular disease, sepsis and ischemic heart disease. It also shows many other biological effects beyond just lowering cholesterol level that include its effects on bone maturation, renal disorders treatment, anticancer and metabolic syndrome.

Keywords: Lovastatin, hydroxymethyl glutaryl-coenzyme A, Aspergillus terreus,submerged fermentation, solid state fermentation.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • EJPMR: JANUARY ISSUE PUBLISHED

    JANUARY issue has been successfully launched on 1 JANUARY 2023.

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 January 2023 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database