AN EXPERIMENTAL STUDY TO EVALUATE THE EFFECT OF SINGLE DOSE OF CLARITHROMYCIN AND GLIBENCLAMIDE COMBINATION IN COMPARISON WITH MONOTHERAPY OF CLARITHROMYCIN AND GLIBENCLAMIDE ON BLOOD GLUCOSE LEVEL IN NEW ZEALAND ALBINO RABBIT.
Rohini Gambre, Akash Khobragade*, Sadiq Patel, Sarita Jaiswar, Kiran Paripelli and Mansi Brid
Introduction: Aim of the study is to evaluate the effect of a combination therapy of Clarithromycin and Glibenclamide given orally as single dose on Blood Glucose level (BGL) at different time intervals 1 hour, 2 hour and 4 hour in albino rabbits. Methods: 20 hrs fasting animal‟s blood was collected for baseline investigations. After feeding, the rabbits were given a single oral dose of 2% gum acacia, Clarithromycin, Glibenclamide and combination of Clarithromycin and Glibenclamide to their respective group. Blood collections were done at 1 hour, 2 hour, 4 hour after drug administration. Results: After 20 hrs fasting mean value of BGL in control, Clarithromycin, Glibenclamide and combination of Clarithromycin and Glibenclamide group were 98.62 ± 0.24, 98.40 ± 0.15, 97.73 ± 0.24 and 98.39 ± 0.13 respectively. After 1 hour the mean values of BGL in Control group, Clarithromycin, Glibenclamide and Clarithromycin + Glibenclamide group were 99.20 ± 0.34, 98.22 ± 0.14, 81.72 ± 0.65 and 79.41 ± 0.39 respectively. At 2 hour the mean value of BGL in Control group, Clarithromycin, Glibenclamide and Clarithromycin + Glibenclamide group were 99.59 ± 0.32, 97.64 ± 0.19, 81.58 ± 0.33, and 77.69 ± 0.25 respectively. By the end of 4 hour the mean value of BGL in Control group, Clarithromycin, Glibenclamide and Clarithromycin + Glibenclamide group were 99.77 ± 0.24, 97.39 ± 0.18, 80.66 ± 0.18 and 78.68 ± 0.44 respectively Conclusion: Combination of Clarithromycin & Glibenclamide shows significant decrease in BGL as compared to Clarithromycin and Glibenclamide alone in non-diabetic albino rabbits at different time intervals for single dose for a single day.
Keywords: Diabetes Mellitus, Clarithromycin, Glibenclamide, BGL.
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