FORMULATION AND EVALUATION OF CREAM CONTAINING CURCUMIN AND LYCOPENE FOR THE ANTIOXIDANT AND ANTIBACTERIAL ACTIVITY
Vinchure Bhagyashree D.*, Kokate Rohit and Patil Shriniwas P.
Objective: The present study was to prepare and evaluate cream containing Curcumin obtained from Curcuma longa L. and Lycopene obtanied from Lycopersiconesculentum M. Both Curcumin and Lycopene have sufficient partition co-efficients (c log p values) to being formulated in the form of cream. Methods: Different o/w emulsions were formulated (F1-F7) by adding different quantities of strearic acid, cetyl alcohol and coconut oil. All formulations were evaluated for different quality control parameters like pH, viscosity and acid value. Results: Formulations F5 and F6 showed good spreadability, they produced non-greasy smear and were found easy to be removed by washing under tap water. All formulations were found to be non-irritant and safe for applications on skin. Conclusion: This study suggested that formulations (F5 and F6) are stable, safe and may gain better patient compliance.
Keywords: Caratenoids, topical formulation, DPPH radical scavenging activity, Well-diffusion method.
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