FORMULATION AND EVALUATION OF CHLORPHENIRAMINE MALEATE FAST DISSOLVING FILM AS AN ANTI ALLERGIC MEDICATION.
Tekade B. W.*, Jadhao U. T., Patil V. R. and Sumit Dhanwade
In the present work, aimed to prepare and evaluate the fast dissolving films containing Chlorpheniramine Maleate, as an anti-allergic drug using different ratios of polymers, Hydroxypropyl methylcellulose E15, Pectin and Aloe Vera gel. The film was prepared by solvent casting technique using Glycerin as a plasticizer, Aspartame as a sweetener. The study examines about the effect of polymers ratio on physicochemicalProperties and drug release potential of films. All the films formulations (F1-F9) were evaluated for their thickness, weight variations, tensile strength, percentage elongation, folding endurance, surface pH, in -vitro disintegration, drug content, In-Vitro drug release. The formulation, (F7) consisting of 200 mg of HPMC E-15 , 100 mg of Pectin, 75 mg of Aloe Vera gel was found to be suitable in the form of fast dissolving film based on the in vitro evaluation studies. The (F7) showed optimum disintegration time and faster drug release 29.00 ±0.60 & 96.49 ± 0.36 respectively.
Keywords: polymers, Hydroxypropyl methylcellulose E15, Pectin and Aloe Vera gel.
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