EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FORMULATION AND EVALUATION OF COX-2 INHIBITOR LOADED GOLD NANOPARTICLES ENRICHED HYDROGEL FOR TREATMENT OF RHEUMATOID ARTHRITIS.

Jessy Shaji* and Seema Darade

ABSTRACT

In the present study, we synthesized Piroxicam Monoethanolamine (PRX-MEA) conjugated gold nanoparticles (PM-AuNPs) by a simple economic, nontoxic green synthesis using Camellia sinesis (green tea) extract as reducing agent and Tween 80 as stabilizer. PM-AuNPs were developed using 19 run, 3 factors and 2-level full factorial design. The particle size and zeta potential of the optimized batch were 51.2 ± 33.8 nm and -30.2 ± 14.2 mV respectively. The loading efficiency of PRX-MEA was found to be 89.05 ± 0.41%. The surface morphology of gold nanoparticles was investigated by TEM. The synthesized particles were largely spherical in shape with a smooth morphology. Selected area electron diffraction (SAED) pattern revealed diffraction patterns of crystalline gold structure. FTIR spectroscopy identified the conjugation of PRX-MEA to the surface of AuNPs. The structural characterization and crystalline nature of PM-AuNPs was determined by XRD. Furthermore, in this study PM-AuNPs enriched hydrogel was fabricated and evaluated for pH, drug content and spreadability. PM-AuNPs dispersion and hydrogel were studied for an in- vitro drug release and skin permeation potential. The cumulative percentage drug released at the end of 48 h was found to be 91.24 ± 3.48%. In transdermal experiments, the steady state flux and the permeability coefficient of PM-AuNPs and PM-AuNPs hydrogel were significantly higher than plain drug solution (p<0.01). In the in-vitro antioxidant assay and in-vivo anti-inflammatory activity PM-AuNPs showed superior activity over PRX-MEA. The results indicate that the developed formulation offers significant protection towards inflammatory effects in rheumatoid arthritis.

Keywords: Piroxicam monoethanolamine, rheumatoid arthritis, gold nanoparticles, green tea, hydrogel, anti-inflammatory.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )