A REVIEW ON DOSE ADJUSMENT IN RENAL FAILURE PATIENTS

*Vishwas A.T.L., Dr. Divyashree N., Nandan H.N. and Bhanushree D. M.

ABSTRACT

Chronic renal failure is an important health care problem throughout the world, with an incidence of 337, 90, 107 and 95 new cases per million inhabitants / year in the United States, Australia, New Zealand and the United Kingdom, respectively. In India it accounts 1 out of 10,000 are affected from chronic kidney disease and one lakh new diagnosis are with end stage renal disease annually. Many medications and their metabolites are eliminated through the kidney. Thus, adequate renal function is important to avoid toxicity. Renal impairment may cause medicines to accumulate or cause toxicity, especially if the medicine has a narrow therapeutic index. Before dose adjustment in renal disease calculation of glomerular filtration rate is needed this reflects the stages of renal disease. Nephrologists and clinical pharmacists can work together to accomplish safe drug prescribing. Clinical pharmacists play an important role in identifying drug related problems, resolving and preventing potential drug therapy problems through careful pharmaceutical practices. This article is an overview of prescribing considerations in the primary care setting for patients with acute and chronic renal impairment

Keywords: clinical pharmacists, Nephrologists, therapeutic index, glomerular filtration rate, renal impairment.