EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ALKALINE PHOSPHATASE (ALP) ELEVATION IS A BIOMARKER FOR CHOLESTASIS, EPSTEIN-BARR VIRUS (EBV) AND OSTEOSARCOMA (REVIEW)

Zahra Ali and Sikander Ali*

ABSTRACT

Alkaline phosphatase is a “metalloenzyme” which at alkaline pH catalyze the hydrolysis of “organic phosphate ester”. Different studies were done to find the function of SALP in Osteosarcoma patients. On analysis it was seen that increased SALP levels are linked with existence of metastasis. The elevated level of SALP is particularly linked with deprived rate of “overall survival” or “event free survival” (OS & EFS). SALP levels hence act as a useful, efficient and suitable biomarker for osteosarcoma. Decreased level of Dickkopf-1 by bortezomib; cause stimulation of osteoblasts, which then cause increase in formation of bone. Increased level of “bone specific alkaline phosphatase” (bALP) and “osteocalcin” specifies the increased bone formation. Elevation of ALP, bilirubin and GGT act as the indicator or marker for cholestasis according “primary lab evaluations”. ALP levels can also rise in late pregnancy because of a “different form of enzyme” produced by placenta but GGT levels are normal here. Common type of “primary EBV hepatitis” is that in which “biochemical abnormalities” of increased ALP are predominant. In almost 75% cases ALP levels are so high that they can be easily detected and calculated. It can be then concluded that ALP when rise from its normal level can act as an indicator for EBV, cholestasis and osteosarcoma.

Keywords: Alkaline Phosphatase Biomarker Cholestasis Epstein-Barr Virus (EBV) Osteosarcoma.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )