ALKALINE PHOSPHATASE (ALP) ELEVATION IS A BIOMARKER FOR CHOLESTASIS, EPSTEIN-BARR VIRUS (EBV) AND OSTEOSARCOMA (REVIEW)
Zahra Ali and Sikander Ali*
Alkaline phosphatase is a â€œmetalloenzymeâ€ which at alkaline pH catalyze the hydrolysis of â€œorganic phosphate esterâ€. Different studies were done to find the function of SALP in Osteosarcoma patients. On analysis it was seen that increased SALP levels are linked with existence of metastasis. The elevated level of SALP is particularly linked with deprived rate of â€œoverall survivalâ€ or â€œevent free survivalâ€ (OS & EFS). SALP levels hence act as a useful, efficient and suitable biomarker for osteosarcoma. Decreased level of Dickkopf-1 by bortezomib; cause stimulation of osteoblasts, which then cause increase in formation of bone. Increased level of â€œbone specific alkaline phosphataseâ€ (bALP) and â€œosteocalcinâ€ specifies the increased bone formation. Elevation of ALP, bilirubin and GGT act as the indicator or marker for cholestasis according â€œprimary lab evaluationsâ€. ALP levels can also rise in late pregnancy because of a â€œdifferent form of enzymeâ€ produced by placenta but GGT levels are normal here. Common type of â€œprimary EBV hepatitisâ€ is that in which â€œbiochemical abnormalitiesâ€ of increased ALP are predominant. In almost 75% cases ALP levels are so high that they can be easily detected and calculated. It can be then concluded that ALP when rise from its normal level can act as an indicator for EBV, cholestasis and osteosarcoma.
Keywords: Alkaline Phosphatase Biomarker Cholestasis Epstein-Barr Virus (EBV) Osteosarcoma.
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