EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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 ICV - 79.57

Abstract

AN EPIDEMIOLOGICAL ANALYSIS OF HERPES ZOSTER AMONG DIFFERENT AGE GROUPS

Elsam Koshy, MD, Hanaasha Kumar, MD and Wu Jianbo*, PhD

ABSTRACT

Introduction: Herpes zoster occurs due to the reactivation of the varicella zoster virus following a primary infection with varicella virus. Its incidence is high among the elderly and immunocompromised patients. Early management with antivirals can reduce severity and complications with herpes zoster. Vaccination for individuals above 60 years can help reduce incidence of herpes zoster. Objective: To analyze the epidemiology of Herpes zoster among different age and gender by comparing their Total hospital stay and Numeric rating scale score on admission and on discharge. Materials and Methods: A retrospective analysis was conducted in 60 patients with herpes zoster infection treated in Zhongnan hospital of Wuhan University, Wuhan, China. All patients were divided into three groups. Group I (n=20) include patients aged <30 years, Group II (n=20) include patients aged 30-60 years and Group III (n=20) include patients aged ≥60 years. A univariate analysis with multiple comparison was performed with total hospital stay, duration at presentation, Numeric rating scale on admission and on discharge. The male and female incidence was performed using chi square test. An independent t test was used to analyze total hospital stay and duration at presentation of both males and females. Results: Among the 60 cases, the total male and female involvement was shown to be non significant (p=0.63). The total hospital stay among Group I and Group II were significant (p=0.047 and p=0.011) and the duration at presentation among Group I was also significant (p=0.02). Thoracic dermatome was involved in 31.6% patients among all age groups. Hypertension was the most common underlying disease with 20% involved among all age groups. Conclusion: Herpes zoster is not a gender specific disease. Treatment with ganciclovir can reduce hospital stay only in patients less than 30 years and patients aged 30-60 years. Thoracic dermatome was most commonly involved in all patients. Ganciclovir is safe and has shown no adverse effects in any patients. Gabapentin is effective in managing pain with a good prognosis in all patients among all age groups. Combination therapy with antivirals, analgesics and neurotropic agents can reduce pain, promotes fast healing and decrease complications.

Keywords: Herpes zoster (HZ); Varicella zoster virus (VZV); Post herpetic neuralgia (PHN).


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia