EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

CELIAC: AT GLANCE (MINI REVIEW)

Tikka Prabhjot Singh, Ritesh Kumar Giri and Wang Hong Ling*

ABSTRACT

Celiac disease is a common chronic inflammatory autoimmune condition caused by intolerance to gluten such as wheat and rye which causes villous atrophy, crypt hyperplasia with infiltration of lymphocytes in genetically predisposed population which is manifested by spectrum of symptoms which varies from mild to signs of malabsorption. Having 0.5 - 1% prevalence in US population and even higher in Africans. Majority of patients express either HLA DQ8 or HLA DQ2 and severity is assessed by Marsh- Oberhuber staging. With the advent of newly serological tests in market for analysis which made the diagnosis as well as screening of patients more accurate like IgA anti-tissue transglutaminase (tTG), which has important component in pathogenesis and diagnosis, IgA anti-endomysial antibodies (EMAs) and total IgA level. Duodenal biopsy are still considered for diagnosis, but in clinical practice in certain circumstances specially, in children diagnosis is made without biopsy. Gluten free diet plan is highly strict, very expensive, socially isolating and mandatory which shows clinical in addition to histological improvements and also reduces complications as well as malignancies. Several years needed for the mucosa to emerge into normal on biopsy. These days high level research is going on for the development of non-dietary approaches, few are under clinical trials with the hope that it will give some kind of advantage to control celiac disease.

Keywords: CD Celiac disease, IEL Intraepithelial lymphocytes, IgA tTG Immunoglobulin A Tissue transglutaminase, IgA EMA immunoglobulin A Endomysial antibody, AGA Antigliadin antibody, DGP Deaminated gliadin peptide.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )