EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

INTRA-ARTICULAR INJECTIONS OF PLATELET-RICH PLASMA COMBINED WITH HYALURONIC ACID VERSUS HYALURONIC ACID ALONE IN TREATMENT OF KNEE OSTEOARTHRITIS.

Seleem N.A.*, Elshereef E., Elhosary A.A., Salama N.M.

ABSTRACT

Osteoarthritis (OA) is a complex disease caused mainly by inflammatory mediators. The last non-operative treatment modality, when other conservative treatments are ineffective is intra-articular (IA) injections with corticosteroids, viscosupplements or blood-derived products. Purpose: The aim of this study was to compare the efficacy of Cellular Matrix-PRP-HA (CM-PRP-HA), a combination of autologous platelet-rich plasma (PRP) and hyaluronic acid (HA) prepared using a dedicated medical device, to HA alone in IA injections for treatment of osteoarthritic knee. Methods: The study involved 100 symptomatic patients with knee cartilage degenerative lesions (Kellgren Lawrence scale grade 0 to III). Fifty patients were treated with IA injections of autologous CM-PRP-HA combination that was repeated 3 times with 3 weeks interval, while the other 50 patients were treated with IA HA injections. All patients were clinically evaluated pretreatment (basal) and at 2,6 and 12-month follow up visits by using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Results: At each follow up visit, both groups showed a highly significant improvement when compared with the basal assessment and the same results were obtained upon comparing 12- month follow up visit with the 2- month one. The infra-group comparison showed, at each follow up evaluation, a significantly higher improvement for the group treated with CM-PRP-HA in respect to HA alone. Conclusion: IA injections of CM-PRP-HA showed more efficacy than HA injections in reducing pain and symptoms of mild to moderate knee degenerative osteoarthritis.

Keywords: knee osteoarthritis, autologous PRP and hyaluronic acid.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia