EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

ETIOLOGICAL, CLINICAL AND EEG PROFILE OF NEONATAL SEIZURES- AN INSTITUTIONAL STUDY

Dr. Roshith J. K.* and Dr. K. N. V. Prasad

ABSTRACT

Background: The occurrence of seizures may be the first indication of a neurological disorder in the neonate. A correct mode of resuscitation soon after birth at first minute of non-vigorous baby, proper monitoring and management of seizure during the post- resuscitation care babies can prevent further occurrence of seizures, deterioration of low agar babies in neonatal care unit and this also helps in better outcome which avoids morbidity, mortality and associated sequel of neonates with seizures. A proper documentation of seizure and clinical profile of seizure can also help with earlier determination of etiology of seizure and help in proper management of the same. Hence this study has been taken up to determine clinical seizure profile, etiology of seizures, bio-chemical and EEG abnormalities in neonatal seizures which would help in early recognition, treatment and better prognosis in neonatal seizures. Objectives: 1. To characterize the clinical profile of neonatal seizure. 2. To identify the etiological profile of neonatal seizure. 3. To perform EEG in neonatal seizure and correlate the clinico-etiological profile. Material and methods: A total of 68 inborn and outborn neonates with seizure were enrolled in the study from Januray 2015 to January 2016. Data including gestational age, birth weight, antenatal events, perinatal events, apgar score, mode of resuscitation, clinical profile like age of onset of seizures, duration of seizure, episodes of seizure, drug used to abort seizure, type of convulsion, seizure associated autonomic changes, lab investigation reports like complete blood count, C-reactive protein, serum biochemistry, cerebro-spinal fluid study –etiology profile of seizure was evaluated, electro encephalogram was performed as soon as early as possible and all were documented in proforma. Results: Of 68 neonates with seizures were included in the study. In the study 91.2% of the neonates were term babies and 8.8%. Male predominance was observed. Out of the neonates enrolled 73.5% of neonates with seizure had low apgar & 77.9% of neonates with seizure who required intermittent positive pressure ventilation were admitted for post -resuscitation care in NICU. In the study 61.7% of neonates had seizures at less than 12 hours of life. Focal clonic type of seizures was more observed (67.2%) as compared to other types. Hypoxic Ischemic Encephalopathy (HIE-II) was a major etiology in the study 42.6%. Among 18 EEG done on neonates with seizures, two had an abnormal EEG pattern. Limitations: In my study EEG could not be performed in all neonates who had seizures due to various reasons. Conclusions: In the present study of etiology in neonatal seizures showed that Hypoxic ischemic encephalopathy -II was the common etiology in 29 neonates (42.6%) and the second major etiology noted in 13 babies (19.1%) was hyponatremia. Focal clonic type of seizure was seen in 67.2% neonates as a common clinical profile of seizure.

Keywords: Electroencephalography (EEG), Hypoxic ischemic encephalopathy, Perinatal Asphyxia.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia