EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF ATORVASTATIN AND CLOPIDOGREL IN TABLET DOSAGE FORM BY RP-HPLC

*Shaik Mohammed Yusuf, Suruchi Samparna, Kolavali Yallareddy, B. Pavani, T. Sivakala

ABSTRACT

A new, simple, accurate and precise reversed phase high performance liquid chromatographic method was developed for the simultaneous quantitative estimation of Atorvastatin Calcium (ATOR) and Clopidogrel Bisulphate (CLOP) in combined capsule dosage form. The method was based on reversed phase liquid chromatography and separation was achieved on a Std kromasil (150 x 4.6 mm, 5). The Eluent was monitored by measuring the absorbance at wavelength 240 nm using a mixture of methanol and 0.01N Sodium dihydrogen ortho phosphate in the ratio of 50:50 (v/v) at pH 4 with a flow rate of 1.0 mL min-1. The Calibration curves were found to be linear in the concentration range of 5-30 μg mL-1 and 37.5-225 μg mL-1 for ATOR and CLOP respectively. The proposed method was validated by testing for its linearity, recovery, repeatability and it was successfully employed for the rapid, specific and sensitive simultaneous quantitative estimation of Atorvastatin Calcium and Clopidogrel Bisulphate in capsules.

Keywords: Atorvastatin, Calcium, Clopidogrel Bisulphate, RP-HPLC, Validation.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )