EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

FLOW CYTOMETRIC PATTERN IN DIAGNOSIS OF CHRONIC LYMPHOCYTIC LEUKEMIA, KING HUSSEIN MEDICAL CENTER EXPERIENCE

Rame Khasawneh, MD, FABMGG, Hala Alsokhni, MD, Bayan Alzghoul, MD, Nabeeha Abbasi, MD, Asim Momani MD*, Nazmi Kamal, MD, FCAP

ABSTRACT

Background: Flow cytometry has an essential role in diagnosing chronic lymphocytic leukemia (CLL) and distinguishing it from other lymphoproliferative diseases (LPD) according to expression of certain markers called cluster of differentiation (CD). Aim: Investigating the pattern of expression of different CD markers in CLL patients at Princess Iman Center for Research and Laboratory Sciences over the period of 1/2011 to 5/2015. Patients and method: 214 patients with peripheral blood (PB) lymphocytosis (lymphocytes count > 5x109) diagnosed as CLL by flow cytometry on PB samples using specific panel including the following markers: CD5, CD19, CD23, CD79b, CD25, CD10, FMC7, sIgM. The age range 37-84 years. The Male to Female ratio is 1.8:1. Results: The expression of the CD markers in CLL patients was as follow: CD5 expressed in 212 patients (99%), CD19 expressed in 214 patients (100%), CD23 expressed in 199 patients (93%), CD79b expressed in 101 patients (47%), CD25 expressed in 97 patients (45%), FMC7 expressed in 17 patients (8%), sIgM expressed in 48 patients (22%), and CD10 was negative in all patients (0%). Conclusion: Flow cytometry is a golden tool for diagnosing CLL. Standardization of the procedure is essential and adding new described monoclonal antibodies related to prognosis and treatment options are recommended.

Keywords: flow cytometry, CLL, CLL panel, LPD, monoclonal antibodies.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia