EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

NEUROPROTECTIVE EFFECTS OF d-?-TOCOTRIENOL RICH FRACTION ON CRUSHED SCIATIC NERVE IN DIABETIC RATS

Bijo Elsy, Aijaz Ahmed Khan* and Veena Maheshwari

ABSTRACT

Background: Peripheral neuropathy in diabetes is believed to be due to the reduced blood flow, altered antioxidant defense mechanism and glycemic status. Aims: Since vitamin E is an antioxidant and its potent neuroprotective form is tocotrienols, the current study was designed to explore the neuroprotective effects of d-δ-tocotrienol rich fraction (d-δ-TRF) on sciatic nerve regeneration not only in healthy but also in diabetic rats. Methods and Material: Diabetes was induced through single subcutaneous injection of alloxan (100 mg/kg). Twenty four albino rats included in the study were divided into four groups; healthy control, diabetic control, healthy treated and diabetic treated. Treated groups were administered d-δ-TRF orally and daily at the dose of 200 mg/kg for three weeks. Right sciatic nerve was approached through mid-thigh skin incision and was crushed with Kocher‟s forceps. Functional, histopathological, histomorphological and biochemical parameters were analyzed on 3rd week. Statistical analysis: One way „ANOVA‟ followed by Tukeys test and Student t test were used for statistical significance. Results: It was noticed that d-δ-TRF significantly improves the antioxidant level, glycemic status and revascularization. It also accelerates regeneration and remyelination of nerve and reorganization of extracellular matrix in both healthy and diabetic rats. Conclusions: It is concluded that the d-δ-TRF is a strong antioxidant and antidiabetic dietary supplement in the management of crushed nerve injury in diabetics.

Keywords: Antioxidant, d-?-tocotrienol rich fraction, Diabetes, Rats, Sciatic nerve.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )