EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

EFFECT OF CALCIUM CHANNEL BLOCKERS AND BETA BLOCKERS AS ADDITIONAL ANTI-HYPERTENSIVE AGENTS ON QUALITY OF LIFE IN T2DM PATIENTS

Sanjay Jaiswal*, Veena M. N., Ashok K. Sharma, Dick B. Brashier

ABSTRACT

Current recommendations exist to control BP < 140/90 mm of Hg for all ages with diabetes. RAS blockers are the anti-hypertensive agents of choice in diabetics with albuminuria. Calcium channel blockers (CCBs) and beta blockers are established anti-hypertensive agents used in T2DM patients. The present study was conducted to compare health related quality of life (HRQoL) index between CCB versus beta blockers as add-on anti-hypertensive agents in T2DM patients. An open-label prospective study was conducted on 100 T2DM patients with poor BP control while on RAS blockers. HRQoL index was measured using EQ-5D VAS scores and its five domains. After 35 weeks, EQ-5D VAS score improved in CCB group while it worsened in beta blocker group and this was highly significant statistically. Beta blocker group also had a higher and significant proportion of patients with pain and anxiety/depression self-rating. The quality of life index by self-assessment was in favour of CCBs compared to beta blockers in T2DM patients. It is suggested therefore that RAS blockers in combination with CCBs maybe a better choice of dual anti-hypertensive therapy in T2DM patients.

Keywords: T2DM patients, RAS blockers, Calcium channel blockers, Beta blockers, HRQoL index EQ-5D.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia