EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR PROTEIN IN ENDOMETRIUM OF WOMEN WITH MENORRHAGIA

*Dr. Kiran B. Mehra, Dr. Nitin M. Gangane, Dr. Shakuntala Chhabra and Dr. Deepti R. Joshi

ABSTRACT

Objective: In the present study we tried to determine expression of Vascular Endothelial Growth Factor (VEGF) protein in endometrium of patients with menorrhagia. Methods: A total of 100 patients with history of menorrhagia were selected for study. Immunohistochemistry was performed on these endometrial biopsy sections to assess VEGF expression in endometrial glands, stroma and endothelium. Results: The results of VEGF expression were compared with phase of menstrual cycle. In late proliferative phase (p value =0.0461) and in late secretory phase (p value =0.0001) there was statistically significant association between VEGF protein expression on glandular luminal surface of endometrium in cases and controls (p value =0.0461). In late proliferative phase (p value =0.0461) and in late secretory phase(p value <0.0001) there was statistically significant association between VEGF protein expression in entire glandular cytoplasm of endometrial glands in cases and controls (p value =0.0461). The findings of the present study clearly observed that glandular luminal secretions were observed more in menorrhagia patients as compared to cytoplasmic positivity in non menorrhagic patients. Conclusion: There was abnormal localization of VEGF in glandular epithelium of menorrhagia patients.

Keywords: Angiogenesis, Endometrium, Menorrhagia, VEGF.