EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR PROTEIN IN ENDOMETRIUM OF WOMEN WITH MENORRHAGIA

*Dr. Kiran B. Mehra, Dr. Nitin M. Gangane, Dr. Shakuntala Chhabra and Dr. Deepti R. Joshi

ABSTRACT

Objective: In the present study we tried to determine expression of Vascular Endothelial Growth Factor (VEGF) protein in endometrium of patients with menorrhagia. Methods: A total of 100 patients with history of menorrhagia were selected for study. Immunohistochemistry was performed on these endometrial biopsy sections to assess VEGF expression in endometrial glands, stroma and endothelium. Results: The results of VEGF expression were compared with phase of menstrual cycle. In late proliferative phase (p value =0.0461) and in late secretory phase (p value =0.0001) there was statistically significant association between VEGF protein expression on glandular luminal surface of endometrium in cases and controls (p value =0.0461). In late proliferative phase (p value =0.0461) and in late secretory phase(p value <0.0001) there was statistically significant association between VEGF protein expression in entire glandular cytoplasm of endometrial glands in cases and controls (p value =0.0461). The findings of the present study clearly observed that glandular luminal secretions were observed more in menorrhagia patients as compared to cytoplasmic positivity in non menorrhagic patients. Conclusion: There was abnormal localization of VEGF in glandular epithelium of menorrhagia patients.

Keywords: Angiogenesis, Endometrium, Menorrhagia, VEGF.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )