EXTRACT OF MORINGA OLEIFERA PLANT IN ALBINO WISTAR RATSâ€.
Dr. Abhijeet Bhagat*, Dr. Alimuddin Shaikh and Dr. Shaikh Huzaif
Introduction: Moringa Oleifera is widely found in Asian subcontinent and it has been used as an analgesic and anti-inflammatory in Indian folk medicine. In this study we compared the analgesic effects of Moringa Oleifera Ethanolic extracts with standard drug diclofenac in Wistar Albino Rats by hot plate method. Methods: Male Wistar albino rats were divided into 5 groups and administered placebo (saline), diclofenac and 3 groups of Moringa Oleifera using 100mg/Kg, 200mg/Kg and 400mg/kg doses. Results: Moringa Oleifera 400mg/Kg produced significant anti-nociceptive action by increasing prolongation of reaction time at 30 min, 60 min and 120 min.Moringa Oleifera (200mg/Kg) also produced significant antinocipetive action by prolongation of reaction time at 30 min, 60 min and 120 min. The Standard drug Diclofenac increased the prolongation of reaction time sustained all throughout the period Conclusion: Ethanolic extracts of Moringa Oleifera leaves exhibits significant anti-nociceptive activity by hot plate model in a dose dependent manner. However the amount of anti-nociceptive action produced was lesser as compared to standard drugs like Diclofenac.
Keywords: Anti-nociception, Diclofenac, Moringa Oleifera.
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