( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Manju Kumari* and Ramandeep Kaur


Antimicrobial agents are effective in treatment of many types of infections, but their overuse promotes the spread of resistant microorganisms that refuse to obey conventional treatments and complicate patient care. One way to overcome the problem of antibiotic resistance is by synthesizing new and effective antimicrobial agents. Long chain fatty acid hydrazide derivatives possess antibacterial, antifungal, antimycobacterial and antiviral activities. Undec-10-enoic acid (Undecylenic acid) is an eleven carbon straight chain unsaturated fatty acid. It is a natural fungicide used against fungal skin infections, such as athlete's foot, ringworm and jock itch. Inspired by above facts, in present study a series of undec-10-enoic acid hydrazide derivatives have been synthesized successfully in appreciable yield (50-80%) and characterized by their physicochemical (Mp/Bp and Rf value) and spectral (IR and NMR) data. Synthesized derivatives were evaluated for their in vitro antimicrobial activities against Gram-positive S. aureus, B. subtilis and Gram-negative E. coli and antifungal activity against A. fumigatus and A. niger by tube dilution method. Antimicrobial screening results indicated that compounds having NO2 (4 and 15), alkoxy (9, 11 and 12), hydroxyl (7, 8, 10, 11 and 13) groups and phenyl substituted azetidinone ring (15-17) were more active against tested strains, but none of them have antimicrobial activity comparable to standard drug Ciprofloxacin and Fluconazole. Further, the presence of electron-withdrawing p-fluoro phenyl group in azetidinone moiety (16) improved the growth inhibition potency specifically against tested fungal strains, A. fumigatus and A. niger.

Keywords: Undec-10-enoic acid, Hydrazide derivatives, Antimicrobial activity.

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  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 March 2024 Issue has been Published, Kindly check it on


    MARCH 2024 issue has been successfully launched on MARCH 2024.

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    EJPMR Impact Factor has been Increased to 7.065 for Year 2024.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia