EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

FORMULATION AND EVALUATION OF CIPROFLOXACIN-COCKLE SHELLS DERIVED CALCIUM CARBONATE ARAGONITE NANOPARTICLES PHYSICOCHEMICAL PROPERTIES MEDIATED IN VITRO BACTERICIDAL ACTIVITY IN SALMONELLA TYPHIMURIUM

Isa Tijani, Zuki Abu Bakar Zakaria, *Sani Ibn Yakubu, Yaya Rukayadi, Alhaji Zubair Jaji

ABSTRACT

Since the use of classical antibiotics in the management of resistant bacterial infections requires high dosage and regular administration for a lengthy duration, the enhanced delivery system that will ensure sustained release of antibiotic to the Site of action is important. We synthesized and formulated ciprofloxacin-cockle shell derived calcium carbonate aragonite nanoparticles (C-CSCCAN), appropriately analysed its physicochemical properties mediated antibacterial activity in Salmonella Typhimurium. The size of the formulated nanoparticles were in the range of 13.94 and 23.95 nm and Zeta potential was optimally negative. Diffraction pattern by X-ray powder diffraction (XRD) revealed strong crystallizations in all the formulations. Fourier-transform (FT-IR) spectra displayed evidence of interactions between the drug and nanoparticles at the molecular level and no change in peaks position was observed prior to and after the synthesis of the nanoparticles. Higher encapsulation (99.5) and loading capacity (5.9%) were attained at ciprofloxacin to nanoparticles ratio 1:17. No burst effect but a sustained drug release was observed from the formulation. C-CSCCAN suspension exhibited higher antibacterial activity than free ciprofloxacin. It was concluded that physicochemical properties of CSCCAN enhanced susceptibility of Salmonella Typhimurium, which could potentially improve the clinical efficacy of ciprofloxacin.

Keywords: Antibacterial resistance, ciprofloxacin, calcium carbonate nanoparticles, physicochemical properties.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia