A COMPARATIVE STUDY ON THE EFFECT OF ROYAL JELLY ON BLOOD GLUCOSE AND SERUM LIPIDS IN STREPTOZOTOCIN INDUCED DIABETIC RATS

*Dr. Mohamad Yosof Rezk

ABSTRACT

Background: Royal jelly (RJ) originating from the pharyngeal glands of the honey bee was found to have various biological activities such as a hypotensive effect, insulin-like action and antitumor activity. Objective: This study was carried out to examine the effect of RJ on the blood glucose level alone and in combination with glibenclamide and metformin and to demonstrate the effect of RJ on serum lipids. Material and methods: a total number of 48 healthy male albino rats were subdivided into 8 equal groups: 1st group, Non diabetic control, 2nd group; was given RJ (300 mg∕Kg), 3rd group diabetic control, 4th group diabetic given RJ 5th group was given Glibenclamide (0.6 mg/kg/B.W), 6th group was given metformin (100 mg/kg/B W), 7th group was given RJ with glibenclamide, 8th group was given RJ with metformin. Results: RJ significantly decreased blood glucose level and caused a further reduction when used in combination with oral hypoglycemic drugs and RJ also significantly reduced serum lipids. Conclusion: RJ has a significant inhibitory effect on blood glucose and serum lipids in streptozotocin induced diabetic rats.

Keywords: diabetes, Streptozotocin, Royal jelly, glibenclamide, metformin, diabetic rats.