EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF CASSIA OBTUSIFOLIA SEED AGAINST PARACETAMOL-INDUCED LIVER DAMAGE IN WISTAR RATS

Huda S. A. A. Mohamed*, Warda S. Abdelgadir, Samia M. A. Elbadawi

ABSTRACT

The hepatoprotective activity of the ethanol extract of Cassia obtusifolia seeds were investigated against paracetamol (PCM) –induced liver damage in rats. Thirty rats were divided into 5 equal groups each of 6 rats. Group 1 (control) animals were fed the normal diet. Group 2 received paracetamol at 1g/kg body weight. Group3 received the standard drug, Silymarin at 70 mg/kg. Group 4 and 5 received the ethanol extract at 250 and 500 respectively. Blood samples were collected at zero time and at the end of the experimental period (7 days) for biochemical parameters and when the rats were sacrificed, and samples of liver were taken for histological study. Liver damage was assessed by liver morphology, histology and estimation of plasma enzyme activities of aspartate aminotransferases (AST), alanine aminotransferase (ALT) and alkaline phospatase (ALP) and the concentration of the total protein, albumin and bilirubin. Treatment with ethanol extract of Cassia obtusifolia significantly (P<0.05) reduced paracetamol-induced elevation in plasma liver marker enzymes and the concentrations of total protein, albumin and bilirubin and ameliorated histopathological liver damage and decreased hemorrhage, congestion, fatty change and hepatic necrosis. Hence Cassia obtusifolia extract can be used as hepatoprotective drug, thereby preventing the process of initiation and progress of hepatocellular diseases.

Keywords: Cassia obtusifolia, Ethanol extract, paracetamol, liver damage.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 February 2023 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

  • EJPMR: FEBRUARY ISSUE PUBLISHED

    FEBRUARY issue has been successfully launched on 1 FEBRUARY 2023.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database