MONITORING OF THYROID HORMONES LEVELS IN DIABETIC MELLITUS TYPE 2 PATIENTS CONTROLLED AND UNCONTROLLED IN SANA’A, YEMEN

Qais Abdu Alwareth, Mohammed Amood AL-Kamarany,*, Ali Almeeri, Ibtisam AL-Zabidy, Saeed Al-Sheibani

ABSTRACT

Background: Diabetes mellitus (DM) is a common endocrine metabolic disorder and variety of thyroid abnormalities may coexist and interact with DM that appears to influence thyroid function. Objective: Therefore, the study aimed to monitor the thyroid hormones levels in DM type 2 patients controlled and uncontrolled in Sana’a, Yemen. Methods: The study included 150 subjects from major public hospitals in Sana'a city, Yemen. 50 were diagnosed with DM type 2 controlled as group I and 50 were diagnosed with DM type 2 uncontrolled as group II. 50 were healthy volunteers as control group. The biochemical parameters namely Fasting Blood Sugar (FBG) and Glycelated Hemoglobin (HBA1c) were assayed in three groups. On the other hand, thyroid hormones levels namely thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) were monitored in the same groups. Data obtained were analyzed using suitable statistical tools. Results: The levels of thyroid hormones in DM type 2 patients controlled and uncontrolled were recorded. The mean of TSH, FT3, and FT4 levels were recorded in three groups. The results were (1.83± 0.791 mU/L , 3.0 ±2.2 mU/L, 1.83 ±0.85 mU/L); (3.47± 0.78 Pg/mL , 2.9 ± 0.74 Pg/mL,4.1± 0 .71 Pg/mL) ; (1.1 ± 0 .212 ng/dl, 1.01 ± 0.33 ng/dl , 1.2 ± 0.14 ng/dl), respectively. The results were observed that different significant (p < 0.05) in in TSH and Free T3 levels between groups I and II. While different significant (p > 0.05) in FreeT3 and Free T4 between group I and III. Also, the different significant in three hormones levels between group II and III. On the other hand , the present study showed 20 % of patients had thyroid dysfunction. 17 % of hypothyroidism and 3% of hyperthyroidism. However, 2% of hypothyroid in controlled patients and 15 % of hypothyroid in uncontrolled patients, while 2% of hyperthyroidism was found in controlled patients and 1 % of hyperthyroidism was recorded in uncontrolled patients. Conclusion: The study outcome concluded that the thyroid dysfunction may progressive in DM type 2 patients uncontrolled as complication

Keywords: Diabetic mellitus, type 2, thyroid hormones, monitoring, controlled, uncontrolled.