FORMULATION AND EVALUATION OF NEBIVILOL MICROSPHERES
B. Manjula*, Sai Charanasree, Sandiri Raveena, Bingi Balachander and Kurra Gangarau
Nebivilol a non-selective beta blocker was formulated as microspheres by using ethyl cellulose as carrier. These ethylcellulose microspheres were prepared by the solvent evaporation method. The prepared microspheres were subjected to various evaluation and in vitro release studies. Highest percentage of entrapment was obtained by increasing the amount of polymer with respect to drug. The particle sizes of the prepared microspheres were determined by optical microscopy and SEM analysis. The prepared microspheres had good spherical geometry with smooth surface as evidence by SEM. The study showed that nebivilol microspheres of 1:2(F3 batch) ratios showed better sustained effect over a period of 12 hours.
Keywords: Nebivilol, Drug profile, Ethylcellulose, Entrapment efficiency, In vitro profile, Microspheres.
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