ACUTE, SUB-CHRONIC TOXICITIES AND ANTIPYRETIC EFFECT OF EXUDATES OF STRYCHNOS CAMPTONEURA GILG & BUSSE (LOGANIACEAE)
Morabandza Cyr Jonas*, Okiemy Evissi-Kouva, Ampa Raoul, Gombe Assoungou Hermann, Ongoka Pascal Robin and Abena Ange Antoine
ABSTRACT
Acute, sub-chronic toxicities and antipyretic activity of S. camptoneura exudates were determined by using classical experimental models. Acute toxicity test (300 and 2000 mg/kg) did not reveal any modification of general behavior, nor mortality of mice but, one notes a significant increase of body weight. The L. D50 of exudates was evaluated to be superior to the dose of 2000 mg/kg. Sub-chronic toxicity at a single dose of 2000 mg/kg after 45 days showed a significant increase of body weight, unchanged hematological parameters (HGB, VGM, platelets and leukocytes); no significant decrease of biochemical parameters (ASAT, ALAT, Bilirubine, creatinine and uric acid) in rat. However, the exudates provoke a significant decrease of glycaemia. At the doses of 300 and 600 mg/kg, exudates reduced significantly hyperthermia induced by the suspension Brewer’s yeast (20%). These results could explain the important use of the exudates of this plant in traditional medicine against all types of fever.
Keywords: Strychnos campteneura, exudates, acute toxicity, sub-chronic toxicity, antipyretic.
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