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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Sami Fatehi Abdalla*, Alfatih Akasha Edries and Hyder Mohammed Ali


Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and their overlap are rare severe cutaneous adverse drug reactions with a fatal potentiality. They are characterized by epidermal necrosis which causes erosions of the mucous membranes, extensive detachment of the epidermis, and severe constitutional symptoms. Drugs are the major causes of SJS\TEN. The types of the drugs depend on the prevalent diseases in the country and the protocols of management in that country. This is a Retrospective hospital based study, was done to detect the morbidity and mortality of SJS / TEN and their overlap, among Sudanese patients admitted to Khartoum Dermatology and Venereology Hospital from April 2004 to April 2014. In our study 150 patients were enrolled, the main age distribution was between 21 - 40 years in (48.7%), 48% of the cases had SJS, 42.7% had TEN and only 9.3% had SJS\TEN overlap. Eighty percent of the patients had no past history of similar condition. The commonest drug reported to precede the development of the disease was antimalarial (artesunate) drug in 20.7% of the cases, followed by the antibiotics Septrin (Cotrimoxazole) in 20%, both contain sulpha group (40.7%) and (ciprofloxacin) in 20% of cases. Other culprit medications were anti-tuberculous, penicillin, carbamazepine, phenytoin, allopurinol and NSAIDS.Patients who dead throughout the last 10 years were 24/150 cases (16%), 14 % due to TEN, 1% with SJS, and 1% with Overlap SJS/TEN. The most implicated causes of deaths were septic shock in 86.5%, respiratory distress in 12.5%, and renal impairment in 1%.

Keywords: TEN, SJS, Morbidity, Mortality.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database