FORMULATION AND EVALUATION OF ZOLMITRIPTAN MICROSPHERE

L. Karpagavalli* and Dr. N. Narayanan

ABSTRACT

In this work, zolmitriptan microsphere was prepared and evaluated. The zolmitriptan microsphere was prepared by emulsion cross linking method using various concentrations of chitosan polymer. The prepared microsphere were characterized for its drug content, particle size, zeta potential, percentage yield, entrapment efficiency and in vitro drug release profile. Based on the in vitro drug release profile of Zolmitriptan microspheres formulations (F1, F2, F3 and F4) formulation F4 was selected as the best formulation which contains the particle size of 3.2μm and drug:polymer in the ratio of 1:1.5 (Zolmitriptan 100mg:150mg of Chitosan). The in vitro % drug release of F4 formulation was 98.17 and it was found to be suitable formulation for the treatment of migraine patients. Hence it can be concluded that the newly formulated controlled release microparticulate drug delivery systems of Zolmitriptan may be ideal and effective to control the migraine attacks by allowing the drug to release continuously for 24 hrs.

Keywords: Zolmitriptan, Emulsion Cross linking, Zeta potential, Migraine, Nasal route.