CLINICAL STUDY TO ASSESS THE EFFICACY OF ARTHROSCOPIC DEBRIDEMENT IN COMBINATION WITH SIHUANG POWDER(???) IN PATIENTS WITH GOUTY KNEE ARTHRITIS
Xingyu Wang, Shuihua Xie*, Xiaopeng Wang, Lei Sun, Hao Ding, Qingyuan Xiong, Jianhua He, Jun Wu, Qianqin Hu and Minghua Xia
Objective: To study the clinical efficacy of arthroscopic debridement in combination with Sihuang Powder(四黄散,SHP) external in the treatment of acute gouty arthritis. Methods: Retrospective comparative study were performed with clinical data of 90 patients with gouty knee arthritis, 30 cases received arthroscopic debridement in combination with SHP(group I), 30 cases received arthroscopic debridement plus the standard drug therapy(group II) and 30 cases took the standard drug administration(group III). The angle of motion(ROM), visual analog scale (VAS) and score of clinical symptoms were collected and compared prior to treatment and at 2,20,48 weeks post-treatment among the three groups. Results: All patients were followed up for 48 weeks at least. Markedly statistic differences in flexion and extension of the knee joint and VAS scores were detected in group I comparison with group II and group III at each time of post-treatment(P<0.05). Remarkable differences in the indices above were observed between group II and group III at each time of post-treatment (P<0.05). Statistically significant differences in ROM and VAS scores were observed between two times points at least in each group(P<0.05). In terms of the curation efficacy, the total clinical efficacy of group I, group II, group III was 96.7%,86.7% and 70.0% at 48 weeks post-treatment, respectively. It was indicated that there was significant difference in the clinical efficacy among the three groups(P<0.05). Conclusion: Arthroscopic debridement in combination with SHP external did show a better efficacy than arthroscopic debridement plus the standard drug therapy and the standard Western medicine orally in this clinical trial. Arthroscopic debridement in combination with SHP external has a promising prospect for the treatment of acute gouty knee arthritis and is worthy of further blind trials with larger samples.
Keywords: Clinical trial. Gouty knee arthritis. Arthroscopic debridement. Sihuang Powder(???,SHP) external.
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