EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

CLINICAL STUDY TO ASSESS THE EFFICACY OF ARTHROSCOPIC DEBRIDEMENT IN COMBINATION WITH SIHUANG POWDER(???) IN PATIENTS WITH GOUTY KNEE ARTHRITIS

Xingyu Wang, Shuihua Xie*, Xiaopeng Wang, Lei Sun, Hao Ding, Qingyuan Xiong, Jianhua He, Jun Wu, Qianqin Hu and Minghua Xia

ABSTRACT

Objective: To study the clinical efficacy of arthroscopic debridement in combination with Sihuang Powder(四黄散,SHP) external in the treatment of acute gouty arthritis. Methods: Retrospective comparative study were performed with clinical data of 90 patients with gouty knee arthritis, 30 cases received arthroscopic debridement in combination with SHP(group I), 30 cases received arthroscopic debridement plus the standard drug therapy(group II) and 30 cases took the standard drug administration(group III). The angle of motion(ROM), visual analog scale (VAS) and score of clinical symptoms were collected and compared prior to treatment and at 2,20,48 weeks post-treatment among the three groups. Results: All patients were followed up for 48 weeks at least. Markedly statistic differences in flexion and extension of the knee joint and VAS scores were detected in group I comparison with group II and group III at each time of post-treatment(P<0.05). Remarkable differences in the indices above were observed between group II and group III at each time of post-treatment (P<0.05). Statistically significant differences in ROM and VAS scores were observed between two times points at least in each group(P<0.05). In terms of the curation efficacy, the total clinical efficacy of group I, group II, group III was 96.7%,86.7% and 70.0% at 48 weeks post-treatment, respectively. It was indicated that there was significant difference in the clinical efficacy among the three groups(P<0.05). Conclusion: Arthroscopic debridement in combination with SHP external did show a better efficacy than arthroscopic debridement plus the standard drug therapy and the standard Western medicine orally in this clinical trial. Arthroscopic debridement in combination with SHP external has a promising prospect for the treatment of acute gouty knee arthritis and is worthy of further blind trials with larger samples.

Keywords: Clinical trial. Gouty knee arthritis. Arthroscopic debridement. Sihuang Powder(???,SHP) external.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )