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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Saiprasanna Behera*, Mrinmoy Gautam, Prasanta Kumar Choudhury, Jayesh Mehta, Mangesh Chandrakant Khadakban


The objective of the study is to evaluate the acute and sub-acute toxicity of Stay-On Power Capsules in rats administered by oral gavage in accordance with the schedule Y of D & C Act (2005). The acute toxicity study of Stay-On Power Capsules was done by up and down method. The animals were fasted for 18 hours with water ad libitum. The Stay-On Power Capsules was administered in six different doses: 250, 500, 750, 1000, 1500, and 2000 mg/kg body weight. Sub-Acute toxicity studies were conducted in rats (n=5/sex/group) by administering single dose of 300, 900, and 1500 mg/kg Stay-On Power Capsules or vehicle (0.5% carboxy-methylcellulose). No mortalities/morbidities and gross lesions observed at necropsy on Day 7 in both sexes. Although there were no effects on body weight, food consumption was increased. The NOAEL was identified as 6 mg/kg/day at all dose levels for both sexes and changes in albumin levels observed at 15 mg/kg/day. Serum enzymes ALT, AST, ALP levels and serum total and direct bilirubin, serum protein, albumin, glucose, haemoglobin, urea, uric acid and creatinine levels were not significantly altered by the treatment. However, the treatment for 28 days decreased LDL, Total cholesterol and triglycerides levels whereas no significant influence on HDL levels were observed at the dose of 5 and 10 mg/kg. In sub-acute toxicity dose was investigated as 10 mg/kg. which didn’t show any toxic effect. Therefore, this study concluded that the Stay-On Power Capsules, at doses investigated, did not provoke toxic effects to the animals.

Keywords: Stay on power capsules, acute and sub-acute toxicity, oral gavage, mortality and morbidity, NOAEL.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia