EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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 ICV - 79.57

Abstract

EVALUATION OF ANTI-INFLAMMATORY, ANALGESIC AND ANTIPYRETIC ACTIVITY OF ECLIPTA ALBA (LINN.) HASSK. IN EXPERIMENTAL ANIMALS.

Dr. Narendrakumar P. Paliwal, Dr. Bhargav M. Purohit , Dr. C.B. Tripathi *, Dr. Hemangini R. Acharya, and Dr. Mahendra K. Patel, M.D.

ABSTRACT

Objective: Eclipta alba (L.) Hassk. (Sanskrit: Bhringaraj) found to contain phytochemicals wadelolactone, eclalbatin, ursolic acid, apigenin, ecliptalbine, verazine and α – amyrin having anti-inflammatory and analgesic properties. The aim of this study, therefore, was to evaluate anti-inflammatory, analgesic and antipyretic activity of single doses (250 mg/kg and 500 mg/kg) of ethanolic extract of leaves of Eclipta alba (L.) Hassk. using λ - carrageenan induced paw edema in Wistar albino rats, hot plate; acetic acid induced nociception in Swiss albino mice and gram -ve lipopolysaccharide induce fever in New Zealand white rabbits respectively. Methods: Decrease in the rat paw edema volume by herb compared to “disease control” group (0.1 ml of 1 % λ - carrageenan) was taken as the index of anti-inflammatory activity. Prolongation of reaction time before and after thermal nociception (55-560C) by herb in mice was taken as index of central analgesic activity. Reduction in number of abdominal constrictions produced by acetic acid (0.6% v/v; 10 ml/kg i.p.) in mice by herb was taken as index of peripheral anlagesic activity. Anti pyretic activity was assessed by decrease in gram -ve lipopolysaccharide (0.2 μg/kg i.v.) induced rectal temperature by herb in the pyretic rabbits. Result: Single dose of 500 mg/kg Eclipta alba produce statistically significant anti-inflammatory and almost similar central analgesic activity with disease control and morphine sulphate (5mg/kg s.c.) respectively. The extract did not shown peripheral analgesic and antipyretic activity. Conclusion – Ethanolic extract of leaves of Eclipta alba has anti-inflammatory and central antinociceptive activity.

Keywords: Anti-inflammatory, analgesic, antipyretic, disease control, Eclipta alba (L.) Hassk.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )