ANTICANCER POTENTIAL OF GREEN SYNTHESIZED SILVER NANOPARTICLES OF SARGASSUM WIGHTII AGAINTS HUMAN PROSTATE CANCER (PC-3) CELL LINE.

Jayaprakash P., Sivakumari K.*, Ashok K., Rajesh S., Prabhu D. and Chandrasekar D.

ABSTRACT

The purpose of this study is to evaluate the anticancer potential of different concentrations of silver nanoparticles biosynthesized by S. wightii on human prostate cancer cell (PC-3) in vitro. Silver nanoparticles were synthesized by the reduction of silver nitrate in the algal aqueous extract. The green synthesis of silver nanoparticles through algal extract was monitored by colour change and various spectroscopic studies. Results of MTT assay showed a decrease in viability of PC-3 cells by increasing the concentration of silver nanoparticles in the tested algae. The maximum inhibitory concentration was found to be 8.84 μg/ml at 48 hrs of incubation when compared to aqueous extract (40.59 μg/ml). Silver nanoparticles formed biologically by S. wightii characterized by a uniform shaped and very small in size and these properties making these silver nanoparticles to possess marked cytotoxic activity.

Keywords: S. wightii, green synthesis, PC-3 cells and MTT assay.