AMELIORATIVE EFFECT OF EMBLICA OFFICINALIS IN POTASSIUM DICHROMATE INDUCED TOXICITY IN RATS
Kader Asen Fathima* and Kalapuram Sivaraman Priyanka
Potassium dichromate is a common inorganic chemical reagent, most commonly used as an oxidizing agent in various laboratory and industrial applications. Potassium dichromate, a Cr (VI) compound, is the most toxic form of Cr (VI) and has been demonstrated to induce toxicity associated with oxidative stress in humans and animals.A single intra peritoneal dose of Potassium dichromate (15mg/kg body weight) dissolved in sterile saline (0.9% Nacl) increased the levels of serum creatinine, urea, activity of SGOT (serum glutamate oxaloacetate transaminase), SGPT (serum glutamate pyruvate transaminase), acid phosphatase (ACP) and alkaline phosphatase (ALP) in serum and reduced the activity of SGOT (serum glutamate oxaloacetate transaminase), SGPT (serum glutamate pyruvate transaminase),alkaline phosphatase in liver tissue and acid phosphatase in kidney. Depletion in reduced glutathione (GSH) and superoxide dismutase (SOD) was observed in liver and kidney tissue. It also caused enhancement in the levels of lipid peroxidation (LPO) in liver and kidney.Pretreatment with E. officinalis at doses of 250 mg/kg body weight, prior to intoxication of Potassium dichromate showed significant reduction in the levels of serum creatinine, urea, activity of SGOT, SGPT, ALP, ACP and tissue LPO. There was also increase in tissue SGOT, SGPT, ALP, ACP, reduced glutathione and SOD. The results suggest that E. officinalis inhibits hepatic and nephro toxicity in wistar rats.
Keywords: Potassium dichromate, Emblica officinalis, Hepatotoxicity, Nephrotoxicity.
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