EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

DIABETES MELLITUS AND MECHANISM OF CHRONIC COMPLICATIONS: REVIEW ARTICLE

Dr. Nidhi S. Patel, Dr. Viren N. Naik* and Dr. C. B. Tripathi

ABSTRACT

Diabetes mellitus (DM) is comprises a group of common metabolic disorders that share the phenotype of hyperglycemia. Complex interaction of genetics, environmental factors and sedentary lifestyle are responsible for its development. Metabolic derangement related with DM induces secondary pathophysiologic changes in multiple organ systems which impose a tremendous burden on the individual with diabetes and the health care system of the country. Worldwide 415 million adults have diabetes and this will rise to 642 million by 2040. In chronic stage DM affects many organ systems, and its complications increase the risk for morbidity and mortality. Many physiological impairments including platelet hyper-reactivity, a tendency for negative arterial remodeling, impaired fibrinolysis coupled with a tendency for thrombosis and coagulation, increased inflammation, and endothelial dysfunction, increases the risk of atherosclerotic vascular disease and other chronic complications like retinopathy, neuropathy. Among these, endothelial dysfunction is an important responsible factor for these pathological manifestations. Various mechanisms have been described for endothelial dysfunction in DM but, most likely are metabolic derangements such as hyperglycemia, excess liberation of free fatty acids (FFAs), and insulin resistance. Additional to these oxidative stress induced reactive oxygen species; inflammation and thrombosis also accentuate endothelial dysfunction. This review article describes mechanism associated with chronic complications of DM in brief.

Keywords: Diabetes mellitus, chronic complications, metabolic derangement, endothelial dysfunction.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia