ACTIVITY OF LEUKOTRIENES IN INFLAMMATION

Bipin Kumar Nayak* and Arun Kumar

ABSTRACT

Leukotrienes (LTs), both LTB4 and Cysteinyl LTs (CysLTs) LTC4, LTD4 and LTE4 are produce a wide variety of inflammation diseases. These are lipid mediators generated from Arachidonic acid via multistep enzymatic process through which Arachidonic is produced from membrane phospholipids through the action of phopholipase A2. LTB4 is known as a potent chemokinetic and chemotactic agent whereas CysLTs are potent contracting agents of smooth muscle in airways and blood vessels. Leukotrienes plat a major role in the pathogenesis of asthma and inflammatory disorder. The affinity of lipid bioeffectors are synthesized during the course of inflammatory reactions and their pharmacological modulation is able to significantly attenuate the clinical manifestations associated with different inflammatory disorder. Selective leukotriene (LTs) inhibitors and receptor antagonists are currently under evaluation in the treatment of various inflammatory diseases.

Keywords: Leukotriene, CysLTs, Inflammation, LTB4.