TRANSFERSOMES: NOVEL APPROACH FOR INTRANASAL DELIVERY
Simran Chaurasia and Sakshi Sharma Dogra*
Nasal route is highly promising for the delivery of drugs exerting local effects in the nose or for therapeutic molecules having systemic or CNS effect. This is attributed to the fact that the nasal epithelium is highly vascularized and permeable, which ensures rapid absorption of the drug. The limitation of short residence time of the formulations in the nose and poor bioavailability of hydrophilic drugs could be overcome by the inclusion of transfersomes. Transfersomes are ultra-flexible lipid bilayer vesicles that have the ability to penetrate the skin. It consists of at least one inner aqueous compartment, which is surrounded by a lipid bilayer with specially tailored properties resulting from the incorporation of “edge activators” into the vesicular membrane. Its ability to cross the membranes has been intensively studied as a result of their elasticity. It enhances the penetration of most of the low as well as high molecular weight drugs. Can be evaluated by entrapment efficiency, vesicle shape, size and diameter; etc. The use of transfersomes carrier results in delivery of high concentration of active agents through the nose, regulated by system composition and their physical characteristics. Thus, this novel technique has got a great potential for overcoming current problems faced by the conventional techniques. However, the attention to study the effect of transferosomes elasticity on brain delivery by the nasal route has not been yet studied.
Keywords: Transfersomes, Elasticity, Intranasal Delivery.
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