SERUM LIPID PROFILE LEVELS IN PREGNANCIES COMPLICATED BY PREECLAMPSIA
Brahma Reddy Malapati*, Dr. Nadeem, Ms. Bhavita Patel, Dr. Rita Shah, Dr. Nillawar AN and Dr. Ruchi
OBJECTIVE: Pre-eclampsia is a disorder that occurs only during
pregnancy. Postpartum changes relating to lipid metabolism may
contribute towards the endothelial lesions observed in preeclampsia.
Thus, the Aim of the present study was to evaluate the lipid profile
among patients who present preeclampsia and correlate these
parameters with 24 hours proteinuria.
DESIGN AND SETTING: Cross-sectional analytical study including
77 pregnant patients at Dhiraj hospitals, S.B.K.S Medical College,
Waghdoia, Vadodara, Gujarat. METHODS: This study involved 42 women with
preeclampsia and 35 healthy pregnant women in the third trimester of pregnancy as controls.
Blood samples were obtained from all the patients, and the serum levels of triglycerides, total
cholesterol, low-density lipoproteins (LDL), high-density lipoproteins (HDL) and very low
density lipoproteins (VLDL) were determined. Cases and controls were matched for maternal
age, gestational week and body mass index. RESULTS: The VLDL and triglyceride values
from the women with preeclampsia were significantly higher than those of the healthy
women. There was a positive correlation between increased proteinuria and higher VLDL and triglyceride levels in patients with preeclampsia. CONCLUSION: Among the patients
with preeclampsia, higher VLDL and triglyceride levels were positively correlated with
proteinuria. These observations indicate that the pregnant women who presented elevated
lipid levels were more susceptible to cardiovascular disorders and, consequently, preeclampsia.
Keywords: Lipids, Hypertension, Pregnancy-induced, Pre-eclampsia, Cholesterol, Hyperlipidemias.
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