P53 REACTIVATING PEPTIDES AS A NOVEL FINDING FOR TREATMENT OF CANCER
*Manju Kumari and Ramandeep Kaur
The p53 is a transcription factor is also known as tumour suppressor gene TP53, involved in regulating the cell responses to DNA damage to support genomic stability. p53 was first identified in 1979 as a cellular protein that bound to the simian virus (SV40) large antigen and a 53-kilodalton phosphoprotein, the product of a 20-kilobase gene on the short arm of human chromosome 17. p53 is usually activated by disruption of its interaction with Mdm2 and it has been shown that cocompartmentalization of both proteins is essential for p53 degradation.
[Full Text Article]