EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

SYNTHESIS, MOLECULAR DOCKING, ANTICANCER ACTIVITY OF SOME NEW HETEROCYCLIC COMPOUNDS CONTAINING THE PYRAZOLYL MOIETY

S.N. ABD Elal* and A.O. Al-Dossary

ABSTRACT

A new series of pyrazolyl derivatives are reported herein. The one pot reaction of pyrazolone 3 with malononitrile, ethyl acetoacetate in presence of aromatic aldehyde, ammonium acetate and/or piperidine gave compounds 4-6. Reaction of compound 4 with ammonium thiocaynate, formamide / formic acid and acetic anhydride gave compounds 7-9. Reaction of compound 5 with acetic anhydride followed by hydrazine hydrate gave compounds 10 and 11 respectively. Reaction of pyrazolone 3 with aromatic aldehyde have also been taken onto consideration to give the α,β –unsaturated ketone 12. Compound 12 was used as key intermediate for preparation of various heterocyclic compounds via its reaction with pyrazolone 3, hydrazine hydrate, hydroxylamine hydrochloride, urea, thiourea, ethyl cyanoacetate / sodium ethoxide, malononitrile / ammonium acetate or sodium ethoxide and also with ethyl acetoacetate / sodium ethoxide. The newly synthesized compounds were characterized by IR, 1HNMR, mass spectral data. The antitumor, molecular docking biological activity has also been taken in consideration.

Keywords: Pyrazolone, Pyrazolopyrimidines, Pyrazolopyrazole, Pyranopyrazole, Biological activity, Molecular docking, Antitum activity.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia