EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

DEXMEDETOMIDINE AS ADJUVANT TO EPIDURAL BUPIVACAINE FOR LAPAROTOMIES- A DOUBLE BLIND PILOT STUDY.

Dr. Asish Karthik* MD, FCA, FIPM, Dr. Shamshad Beegam T. S., MD, Dr. Shuaib Bin Aboobacker, MD, Dr. Sruthi Ramachandran MBBS, Dr. K. N. Radhakrishnan

ABSTRACT

Background and Aim: Epidural anaesthesia is widely practiced for laparotomy. Adjuvant to local anaesthetics improves the quality and duration of this route and dexmedetomidine can be a useful adjuvant. We undertook a double blind study comparing 12 ml of 0.5% bupivacaine with a combination of same dose bupivacaine and 1 mcg per kilogram of dexmedetomidine as adjuvant, administered epiduraly, in laparotomy. Material and Methods: The participants of the study were randomly allocated in to two groups of 30 each; group B with epidural bupivacaine (0.5%) and group D,with 0.5% bupivacaine and 1mcg per Kg of dexmedetomidine. We compared between the magnitude of variations in heart rate and mean arterial pressure, onset and duration of analgesia and surgical condition provided. Result: Variation in the heart rate of group B and group D (22.25±13.46bpm,18.64±9.91bpm: p 0.248) and MAP are (25.56±10.15 mm of Hg,26.46±10.48mm of Hg: p 0.737). The Chi Square value comparing surgical condition provided by the groups is 1.741. Onset of blockade of gp B and gp D are 10.56±2.61mins and 5.11±1.25,p value < 0.05. Duration of analgesia in gp B and gp D are 172.81±83.99mins and 367.14±251.08mins, p< 0.05. Conclusion; Addition of dexmedetomidine to bupivacaine in epidural anaesthesia has comparable hemodynamics with earlier onset and prolonged postoperative analgesia.

Keywords: Epidural dexmedetomidine, adjuvant, laparotomy.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )