EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

DIURETIC ACTIVITY OF FLAVONOID COMPOUND ISOLATED FROM GMELINA ARBOREA FRUITS EXTRACT

Bhabani Shankar Nayak*, P. Ellaiah, Subas Chandra Dinda, Bibhu Prasad Moharana, Manasi Khadanga and Sarala Nayak

ABSTRACT

Background: The plant Gmelina arborea has been traditionally used in India for several medicinal purposes like anthelmintic, diuretic, antibacterial, hepatoprotective, anti-inflammatory, antioxidant and antidiabetic. It contains phytoconstituents like alkaloids, carbohydrates, anthraquinone glycosides, gums, mucilages, tannins, phenolic compounds and flavonoids. Aims: The objective of present study is to isolate a compound from ethanolic extract of G. arborea and to explore the diuretic activity of isolated compound. Material and methods: The isolation of compound was done by column and thin layer chromatographic methods. The isolated compound was characterized to elucidate its structure by spectroscopic methods like ultraviolet, infrared, nuclear magnetic resonance and mass spectroscopy. The diuretic activity of isolated compound was evaluated by Lipschitz test methods using Wistar rats as animal model. Statistical analysis used: All data are verified for statistically significant by using one way ANOVA at 5 % level of significance (p < 0.05). Results: A flavonoidal compound was isolated as yellow color crystal with melting point 177±1 °C with molecular formula C16H15O5 and IUPAC name 5,7-dihydroxy-4-methoxy flavone. Urine volume was significantly increased in comparison to normal and standard control groups. The excretion of sodium was also increased by the compound. The diuretic effect of the compound was comparable to that of the reference standard (Furosemide). Conclusion: It could be concluded that the isolated compound is a flavonoid and it possess diuretic activity.

Keywords: Gmelina arborea, Flavonoid, Diuretic, Lipschitz.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )