SYNTHESIS, CHARACTERIZATION OF SCHIFF BASE DIVALENT MACROCYCLES DERIVE FROM 1, 2-DI(1H-INDOL-1-YL)ETHANE-1,2-DIONE AND THIOCARBOHYDRAZIDE WITH THEIR ANTIBACTERIAL EVALUATION
Vidhi Singh and Gajendra Kumar*
ABSTRACT
The macrocycles [{M(C38H28N12S2)X}X2] of Cu(II), Zn(II) and Ni(II) with Schiff base ligand (C38H28N12S2) obtained through the condensation of 1H-indol, diethyl oxalate and thiocarbodihydrazide. The newly formed compound have been characterized with the help of magnetic measurements, elemental analysis, condensation measurements and their structure configuration have been determined by various spectroscopic: Electronic, IR, 1H NMR, 13C NMR, GCMS techniques. The electronic spectra of the complexes indicate an octahedral geometry of the center metal ion. These compounds were tested for their antibacterial potential against the bacteria: Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa.
Keywords: Schiff base, Macrocycles, Biological Evaluation, Spectroscopic study.
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