EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

“EVALUATION OF CARDIOPROTECTIVE EFFECT OF COW URINE ARK ON ISOPRENALINE INDUCED MYOCARDIAL INJURY IN WISTAR ALBINO RATS”

Dr. Arunkumar D. Rana, Dr. Bhargav M. Purohit*, Dr. Geeta B. Kharadi, Dr. Vishal K. Vadgama, Dr. Alpeshpuri P. Goswami, Dr. Narendra K. Paliwal, Dr. Chandrabhanu B. Tripathi

ABSTRACT

The present study was conducted to evaluate the cardioprotective effect of Cow urine ark (CUA) by isoprenaline-induced myocardial ischemia in male Wistar albino rats. Acute toxicity study was performed. Chemical analysis of CUA contents was carried out. For present study, total 72 rats were randomized into 6 groups: normal saline, isoprenaline control, CUA, Low dose (1.4 ml/kg) and High dose (2.8 ml/kg) CUA and Carvedilol (1 mg/kg) group. Myocardial injury was produced by subcutaneous injection of isoprenaline (85 mg/kg) on day 27th and 28th. ECG changes, cardiac injury markers, antioxidant markers and histopathological changes were observed. Study results show decrease in troponin - I levels in Low and High dose CUA group as compared to Isoprenaline control group and histopathological changes show statistically significant cardioprotective effect with high dose CUA. So we can conclude that high dose CUA shows the cardioprotective effect but further study with higher doses is necessary.

Keywords: Cardioprotective; Carvedilol; CUA; Isoprenaline; Myocardial injury.

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