EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

“EVALUATION OF CARDIOPROTECTIVE EFFECT OF COW URINE ARK ON ISOPRENALINE INDUCED MYOCARDIAL INJURY IN WISTAR ALBINO RATS”

Dr. Arunkumar D. Rana, Dr. Bhargav M. Purohit*, Dr. Geeta B. Kharadi, Dr. Vishal K. Vadgama, Dr. Alpeshpuri P. Goswami, Dr. Narendra K. Paliwal, Dr. Chandrabhanu B. Tripathi

ABSTRACT

The present study was conducted to evaluate the cardioprotective effect of Cow urine ark (CUA) by isoprenaline-induced myocardial ischemia in male Wistar albino rats. Acute toxicity study was performed. Chemical analysis of CUA contents was carried out. For present study, total 72 rats were randomized into 6 groups: normal saline, isoprenaline control, CUA, Low dose (1.4 ml/kg) and High dose (2.8 ml/kg) CUA and Carvedilol (1 mg/kg) group. Myocardial injury was produced by subcutaneous injection of isoprenaline (85 mg/kg) on day 27th and 28th. ECG changes, cardiac injury markers, antioxidant markers and histopathological changes were observed. Study results show decrease in troponin - I levels in Low and High dose CUA group as compared to Isoprenaline control group and histopathological changes show statistically significant cardioprotective effect with high dose CUA. So we can conclude that high dose CUA shows the cardioprotective effect but further study with higher doses is necessary.

Keywords: Cardioprotective; Carvedilol; CUA; Isoprenaline; Myocardial injury.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )