EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

IMPACT OF SUPEROXIDE DISMUTASE (SOD) AND GLUTATHIONE REDUCTASE (GR) ACTIVITY AS MARKERS OF OXIDATIVE-STRESS AND THEIR ROLE IN INFLAMMATION WITH OSTEOARTHRITIS PATIENTS

*Beauty Hatai, Apurba Ganguly, Sandip Bandopadhyay, Sudip K. Banerjee and Jubilee Hatai

ABSTRACT

Introduction: Osteoarthritis afflicts millions of individuals across the world resulting in impaired quality of life and increased health costs. It is an important issue for both the individual and society. Osteoarthritis is a slow progressive and inflammatory disorder of synovial joints. It is a clinical syndrome in which low grade inflammation results in pain in the joints, caused by abnormal wearing of the cartilage that covers and acts as a cushion inside joints and destruction or decrease of synovial fluid that lubricates those joints. The term „Oxidative stress‟ is a physiological condition or to the situation of a serious imbalance between production of reactive oxygen species/reactive nitrogen species (ROS/RNS) and antioxidant defense. Excessive ROS accumulation will lead to cellular injury. Oxygen-derived free radicals are generated during oxidative metabolism and energy production in the body and are involved in regulation of signal transduction and gene expression, activation of receptors, oxidative damage to cell components, as well as in aging and age related degenerative diseases. The disbalance between free radical burden and cellular scavenging mechanisms is a relevant part of OA pathogenesis. Oxidative stress is likely not only to promote cartilage destruction but also to be involved in inflammative transformation, promoting the transition from clinically silent cartilage destruction to apparent OA. Objective: To determine the level of blood marker of cellular oxidative stress (SOD,GR) with osteoarthritis patients by using antioxidant enzymes systems, as well as to determine the significant level (p value) of SOD and GR activity of controls and osteoarthritis patients(combined, >45 and45 years) showed a significant increase (p<0.001; p<0.001) as compared to controls, besides it was studied that GR activity of osteoarthritis patients in combined group showed a significant increase (p<0.001) as compared to controls, and in two separate age groups(age45 years) showed a significant increase (p<0.001; p<0.001) as compared to controls. Conclusion: As, this study concerning the significant increase then it indicate that this result may be as a disruption of homeostatic balance between the entire antioxidant and pro-antioxidant causing an increase in oxidative burden, one of the many etiological causes of chronic inflammation.

Keywords: Osteoarthritis; Inflammation; Oxidative stress; Reactive oxygen Species; Reactive nitrogen species; Oxidative metabolism; Antioxidant; Pro-antioxidant; Superoxide dismutase; Glutathione reductase.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )